Registered Nurse salary in St. Louis
A registered nurse in the St. Louis, MO area earns an estimated $83,180 a year ($39.99/hr) — about 15% below the U.S. average, with most between $77,410 and $100,230. City figures are estimates based on national pay for the role and local cost of living — a starting point, not a guaranteed local wage.
Registered Nurse — St. Louis, MO
Verified public wage dataMedian annual pay
$83,180
-15% vs nationalHourly
$39.99/hr
- Typical range
- $77,410–$100,230
- What most nurses earn
- High end
- $104,460
- Top earners
- Entry level
- $63,440
- Newer nurses
Part of Registered Nurse pay in Missouri.
Other nursing roles in St. Louis
Compare estimated pay for related roles in this metro.
What affects registered nurse pay in St. Louis
Largest Missouri metro. For a registered nurse, local pay also reflects the concentration of major hospital systems and academic medical centers, union contracts, shift differentials, unit acuity, and how competitive staffing is. Nights, weekends, and critical-care specialties typically add to base pay. Use the calculator to estimate your own.
Where this figure comes from
This is the actual median wage reported for St. Louis, MO in official U.S. government wage data — about 15% below the U.S. average. It is measured from employer-reported payroll, not estimated from a national average.
In St. Louis, MO, the lowest-paid 10% earn about $63,440 and the highest-paid 10% about $104,460. Where you land depends on specialty, shift, overtime, union status, employer type, and years of experience.
Source year: 2025. Updated when new official wage data is published.
How to use this metro figure
- It’s the median actually reported for St. Louis — half of nurses earn more, half earn less. A midpoint, not an offer you’re guaranteed.
- Your actual pay shifts with role and specialty, care setting, shift, overtime, union status, and years of experience — so compare a role-specific page and personalize the calculator.
- Reviewed salary submissions from nurses in St. Louis make this page more precise over time.
Registered Nurse salary in St. Louis — FAQ
- How much does a registered nurse make in St. Louis?
- A registered nurse in the St. Louis, MO area earns an estimated $83,180 a year — about $39.99 an hour, with most between $77,410 and $100,230. That's about 15% below the national average. This is an estimate based on the role's national pay and St. Louis's local pay level, not a guaranteed local wage.
- Is St. Louis a good place for registered nurses?
- On pay, St. Louis runs about 15% below the national average for registered nurses. Big-city wages are often offset by a higher cost of living, so weigh the estimated $83,180 against local housing and expenses.
- How does St. Louis registered nurse pay compare to Missouri overall?
- Statewide, Missouri registered nurses earn an estimated $81,780 a year, versus about $83,180 in St. Louis. Metro pay can run above or below the state figure depending on hospital concentration and local demand.
- Why are some figures verified and others estimates?
- National pay for the main nursing roles — registered nurses, LPNs/LVNs, nurse practitioners, CRNAs, nurse midwives, and nursing assistants — comes from verified public wage data. State, city, and specialty figures that aren't reported on their own start from that national pay and are labeled "Estimated" or "Specialty estimate." We never show an estimate as a verified figure.
Source & confidence— A verified figure from official U.S. public wage data.
BLS OEWS (May 2025, metro)
St. Louis, MO figures are published directly by the U.S. Bureau of Labor Statistics for St. Louis, MO-IL (May 2025). They are not estimated or adjusted.
Source year 2025. Last reviewed July 17, 2026. Full methodology
Estimated figure — national registered nurse pay adjusted for St. Louis. Last reviewed July 17, 2026.